PFM01
- Product Name
- PFM01
- CAS No.
- 1558598-41-6
- Chemical Name
- PFM01
- Synonyms
- PFM01;PFM01 >=98% (HPLC);(Z)-5-(4-Hydroxybenzylidene)-3-isobutyl-2-thioxothiazolidin-4-one;(5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone;4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-, (5Z)-;Inhibitor,derivative,MRE11,PFM-01,NHEJ,Mirin,DSB,endonuclease,N-alkylated,PFM01,PFM 01,inhibit
- CBNumber
- CB64670537
- Molecular Formula
- C14H15NO2S2
- Formula Weight
- 293.4
- MOL File
- 1558598-41-6.mol
PFM01 Property
- Boiling point:
- 435.2±55.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO
- form
- powder
- pka
- 8.59±0.30(Predicted)
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1735
- Product name
- PFM01
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $114
- Updated
- 2024/03/01
- Product number
- SML1735
- Product name
- PFM01
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $464
- Updated
- 2024/03/01
- Product number
- 6222
- Product name
- PFM01
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 6222
- Product name
- PFM01
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $315
- Updated
- 2021/12/16
- Product number
- P293993
- Product name
- PFM01
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
PFM01 Chemical Properties,Usage,Production
Biochem/physiol Actions
PFM01 is a cell-permeable N-alkylated Mirin (Sigma Cat. No. 475954) derivative that selectively inhibits against MRE11 endo-, but not exo-, nuclease activity. PFM01 targets MRE11 at a site near the dimer interface, distinct from that occupied by Mirin and PFM39 to allow disruption of the ssDNA-binding groove and selective inhibition against MRE11 endo-, but not exo-, nuclease activity. While both endonuclease and exonuclease activities are required for MRE11-mediated homologous recombination (HR) repair, only FM01 (100 μM), but not the exonuclease inhibitors Mirin (500 μM) and PFM39 (100 μM), rescues G2-phase double-strand break (DSB) repair defect in HR protein BRCA2-deficient HSC62-hTERT fibroblasts following ionizing irradiation (IR) by blocking HR initiation and thereby allowing non-homologous end joining (NHEJ) to proceed.
storage
Store at -20°C